Prehospital low titer group O whole blood is feasible and safe: Results of a prospective randomized pilot trial.

ABSTRACT:

Introduction

Low titer group O whole blood (LTOWB) resuscitation is increasingly common in both military and civilian settings. Data regarding the safety and efficacy of prehospital LTOWB remain limited.

Methods

We performed a single-center, prospective, cluster randomized, prehospital through in-hospital whole blood pilot trial for injured air medical patients. We compared standard prehospital air medical care including red cell transfusion and crystalloids followed by in-hospital component transfusion to prehospital and in-hospital LTOWB resuscitation. Prehospital vital signs were used as inclusion criteria (systolic blood pressure ≤90 mm Hg and heart rate ≥108 beats per minute or systolic blood pressure ≤70 mm Hg for patients at risk of hemorrhage). Primary outcome was fe

SUBMITTER: Guyette FX 

PROVIDER: S-EPMC9038638 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature