Transcriptome Analysis Reveals Intrinsic Proinflammatory Signaling in Healthy African American Skin.

ABSTRACT: Differences in the morphology and physiology of darkly pigmented skin compared with those of lightly pigmented skin are well-recognized. There are also disparities in the prevalence and clinical features for many inflammatory skin diseases, including atopic dermatitis and psoriasis; however, the underlying mechanisms are largely unknown. We compared the baseline gene expression in full-thickness skin biopsies from healthy individuals self-reporting as African American (AA) or as White non-Hispanic (WNH). Extensively validated RNA-sequencing analysis identified 570 differentially expressed genes in AA skin, including Igs and their receptors such as FCER1G; proinflammatory genes such as TNFα and IL32; and epidermal differentiation cluster and keratin genes. Differentially expressed genes wer

SUBMITTER: Klopot A 

PROVIDER: S-EPMC9038646 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature