Excessive alcohol consumption and the risk of knee osteoarthritis: a prospective study from the Osteoarthritis Initiative.

ABSTRACT:

Objective

To examine the association of alcohol consumption with risk of incident knee osteoarthritis (OA) in a large prospective cohort study.

Design

In the Osteoarthritis Initiative, 2,846 participants aged 45-79 years and free from radiographic knee OA in at least one knee at baseline were followed up to 96 months. Information on baseline alcohol consumption was obtained from the Block Brief Food Frequency Questionnaire. Incident cases of radiographic knee OA (ROA) were defined as Kellgren-Lawrence grade changing from zero or one to ≥ two during the follow-up time. Incident symptomatic OA (SxOA) was defined as ROA with knee pain worsening. The Cox proportional hazards models were used to assess the independent association between alcohol consumption and risk of knee.

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SUBMITTER: Liu T 

PROVIDER: S-EPMC9038654 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature