Lung transplant recipients with idiopathic pulmonary fibrosis have impaired alloreactive immune responses.

ABSTRACT:

Background

Telomere dysfunction is associated with idiopathic pulmonary fibrosis (IPF) and worse outcomes following lung transplantation. Telomere dysfunction may impair immunity by upregulating p53 and arresting proliferation, but its influence on allograft-specific immune responses is unknown. We hypothesized that subjects undergoing lung transplantation for IPF would have impaired T cell proliferation to donor antigens.

Methods

We analyzed peripheral blood mononuclear cells (PBMC) from 14 IPF lung transplant recipients and 12 age-matched non-IPF subjects, before and 2 years after transplantation, as well as PBMC from 9 non-transplant controls. We quantified T cell proliferation and cytokine secretion to donor antigens. Associations between PBMC telomere length, measured b

SUBMITTER: Wang P 

PROVIDER: S-EPMC9038662 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature