Proliferative cells in racemose neurocysticercosis have an active MAPK signalling pathway and respond to metformin treatment.

ABSTRACT: Racemose neurocysticercosis is an aggressive infection caused by the aberrant expansion of the cyst form of Taenia solium within the subarachnoid spaces of the human brain and spinal cord, resulting in the displacement of the surrounding host tissue and chronic inflammation. We previously demonstrated that the continued growth of the racemose bladder wall is associated with the presence of mitotically active cells but the nature and control of these proliferative cells are not well understood. Here, we demonstrated by immunofluorescence that the racemose cyst has an active mitogen-activated protein kinases (MAPK) signalling pathway that is inhibited after treatment with metformin, which reduces racemose cell proliferation in vitro, and reduces parasite growth in the murine model of Taenia

SUBMITTER: Orrego MA 

PROVIDER: S-EPMC9038666 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature