Biomarkers in Moderate to Severe Pediatric Traumatic Brain Injury: A Review of the Literature.

ABSTRACT:

Background

Despite decades of research, outcomes in pediatric traumatic brain injury (pTBI) remain highly variable. Brain biofluid-specific biomarkers from pTBI patients may allow us to diagnose and prognosticate earlier and with a greater degree of accuracy than conventional methods. This manuscript reviews the evidence surrounding current brain-specific biomarkers in pTBI and assesses the temporal relationship between the natural history of the traumatic brain injury (TBI) and measured biomarker levels.

Methods

A literature search was conducted in the Ovid, PubMed, MEDLINE, and Cochrane databases seeking relevant publications. The study selection and screening process were documented in a Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram. Extr

SUBMITTER: Munoz Pareja JC 

PROVIDER: S-EPMC9038667 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature