Outcomes and Perioperative Nutritional Management in a Porcine Model of Short Bowel Syndrome.

ABSTRACT:

Introduction

Short bowel syndrome (SBS) results from significant intestinal loss and is characterized by insufficient absorption of nutrients and fluids. Preclinical large animal SBS models typically require parenteral nutrition (PN) support and may not be appropriate for studying interventions to improve intestinal absorption or adaptation. Here, we describe the development of a porcine SBS model that does not require PN support.

Methods

Eight male Yorkshire piglets underwent either a 75% or 90% jejunoileal resection (n = 5) or no resection (n = 3). Continuous enteral nutrition (EN) was provided via a gastrostomy tube. The final SBS model consisted of a 75% resection and nutrition provided via combination EN (60%) and per oral pig chow (40%). Body weight and concentration o

SUBMITTER: Tsikis ST 

PROVIDER: S-EPMC9038684 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature