Association between treatment-related lymphopenia and survival in glioblastoma patients following postoperative chemoradiotherapy.

ABSTRACT:

Purpose

Our study investigated the association between treatment-related lymphopenia and overall survival (OS) in a series of glioblastoma (GBM) patients. We also explored clinical and dosimetric predictors of lymphocytes depletion.

Methods

Between 2015 and 2019, 64 patients were treated at the same institution with postoperative chemoradiotherapy. Peripheral lymphocyte count (PLC) data and dose-volume histogram parameters were collected. Radiotherapy (RT) schedule consisted in standard total dose of 60 Gy in 30 daily fractions, with concomitant and adjuvant temozolomide (TMZ). Posttreatment acute absolute lymphopenia (nadir AAL) was calculated as a PLC lower than 1.0 × 10³/mm³. Acute relative lymphopenia (ARL) was expressed by the nadir-PLC/baseline-PL

SUBMITTER: Mapelli R 

PROVIDER: S-EPMC9038819 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature