Validation of an automatic tool for the rapid measurement of brain atrophy and white matter hyperintensity: QyScore®.

ABSTRACT:

Objectives

QyScore® is an imaging analysis tool certified in Europe (CE marked) and the US (FDA cleared) for the automatic volumetry of grey and white matter (GM and WM respectively), hippocampus (HP), amygdala (AM), and white matter hyperintensity (WMH). Here we compare QyScore® performances with the consensus of expert neuroradiologists.

Methods

Dice similarity coefficient (DSC) and the relative volume difference (RVD) for GM, WM volumes were calculated on 50 3DT1 images. DSC and the F1 metrics were calculated for WMH on 130 3DT1 and FLAIR images. For each index, we identified thresholds of reliability based on current literature review results. We hypothesized that DSC/F1 scores obtained using QyScore® markers would be higher than the threshold. In contrast, RVD scores wo

SUBMITTER: Cavedo E 

PROVIDER: S-EPMC9038894 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature