Unveiling OASIS family as a key player in hypoxia-ischemia cases induced by cocaine using generative adversarial networks.

ABSTRACT: Repeated cocaine use poses many serious health risks to users. One of the risks is hypoxia and ischemia (HI). To restore the biological system against HI, complex biological mechanisms operate at the gene level. Despite the complexity of biological mechanisms, there are common denominator genes that play pivotal roles in various defense systems. Among these genes, the cAMP response element-binding (Creb) protein contributes not only to various aspects of drug-seeking behavior and drug reward, but also to protective mechanisms. However, it is still unclear which Creb members are key players in the protection of cocaine-induced HI conditions. Herein, using one of the state-of-the-art deep learning methods, the generative adversarial network, we revealed that the OASIS family, one of the Creb

SUBMITTER: Lee K 

PROVIDER: S-EPMC9038918 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature