Lung perfusion during veno-venous extracorporeal membrane oxygenation in a model of hypoxemic respiratory failure.

ABSTRACT:

Background

Veno-venous extracorporeal membrane oxygenation (ECMO) provides blood oxygenation and carbon dioxide removal in acute respiratory distress syndrome. However, during ECMO support, the native lungs still play an important role in gas exchange, functioning as a second oxygenator in series with ECMO. The hypoxic vasoconstriction mechanism diverts regional blood flow within the lungs away from regions with low oxygen levels, optimizing ventilation/perfusion matching. ECMO support has the potential to reduce this adaptive pulmonary response and worsen the ventilation/perfusion mismatch by raising venous oxygen partial pressure. Thus, the objective of this study was to evaluate the effect of ECMO on regional pulmonary perfusion and pulmonary hemodynamics during unilateral venti

SUBMITTER: Mendes PV 

PROVIDER: S-EPMC9038965 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature