The Many Faces of G Protein-Coupled Receptor 143, an Atypical Intracellular Receptor.

ABSTRACT: GPCRs transform extracellular stimuli into a physiological response by activating an intracellular signaling cascade initiated via binding to G proteins. Orphan G protein-coupled receptors (GPCRs) hold the potential to pave the way for development of new, innovative therapeutic strategies. In this review we will introduce G protein-coupled receptor 143 (GPR143), an enigmatic receptor in terms of classification within the GPCR superfamily and localization. GPR143 has not been assigned to any of the GPCR families due to the lack of common structural motifs. Hence we will describe the most important motifs of classes A and B and compare them to the protein sequence of GPR143. While a precise function for the receptor has yet to be determined, the protein is expressed abundantly in pigment pro

SUBMITTER: Bueschbell B 

PROVIDER: S-EPMC9039016 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature