In vitro effects and mechanisms of action of Bidens pilosa in Trypanosoma brucei.

ABSTRACT:

Background and aim

African trypanosomiasis poses serious health and economic concerns to humans and livestock in several sub-Saharan African countries. The aim of the present study was to identify the antitrypanosomal compounds from B. pilosa (whole plant) through a bioactivity-guided isolation and investigate the in vitro effects and mechanisms of action against Trypanosoma brucei (T. brucei).

Experimental procedure

Crude extracts and fractions were prepared from air-dried pulverized plant material of B. pilosa using the modified Kupchan method of solvent partitioning. The antitrypanosomal activities of the fractions were determined through cell viability analysis. Effects of fractions on cell death and cell cycle of T. brucei were

SUBMITTER: Dofuor AK 

PROVIDER: S-EPMC9039108 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature