Spirulina supplementation improves bone structural strength and stiffness in streptozocin-induced diabetic rats.

ABSTRACT: Spirulina (blue-green algae) contains a wide range of nutrients with medicinal properties which include β-carotene, chromium, and moderate amounts of vitamins B₁₂. This study aims to determine the preventive effect of spirulina against bone fragility linked to type 2 diabetes mellitus. Thirty Sprague-Dawley rats were divided into five groups (n = 6) and diabetes was induced using streptozocin. Rats with a plasma glucose level of 10 mmol/L and above were orally treated for twelve weeks with either a single dose of spirulina, metformin, or a combined dose of spirulina + metformin per day. After the treatment, blood and bones were taken for biochemical analysis, three-dimensional imaging, 3-point biomechanical analysis, histology imaging and gene expression using qPCR. Results show

SUBMITTER: Ekeuku SO 

PROVIDER: S-EPMC9039118 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature