Quantifying Societal Burden of Radiation-Induced Cardiovascular Events in Breast Cancer Survivors.

ABSTRACT:

Background and purpose

Radiation-induced cardiotoxicity is an important health concern for clinicians during treatment of breast cancer (BC) patients. Underlying mechanisms are well-documented, whereas little is known about the societal impact of this long-term effect. This study aimed to quantify the additional burden of radiation-induced cardiovascular (CV) diseases in BC survivors.

Materials and methods

Conventional health economic modelling techniques were applied to estimate attributed CV-related costs and disutility in a hypothetical cohort of BC survivors. A situation in which radiotherapy caused an additional CV risk was compared with a situation in which this risk was not taken into account. Uncertainty was assessed via deterministic and probabilistic sensiti

SUBMITTER: Kimpe E 

PROVIDER: S-EPMC9039176 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature