The Effect of the 5-HT₄ Agonist, Prucalopride, on a Functional Magnetic Resonance Imaging Faces Task in the Healthy Human Brain.

ABSTRACT: Depression is a common and often recurrent illness with significant negative impact on a global scale. Current antidepressants are ineffective for up to one third of people with depression, many of whom experience persistent symptomatology. 5-HT₄ receptor agonists show promise in both animal models of depression and cognitive deficit. We therefore studied the effect of the 5-HT₄ partial agonist prucalopride (1 mg daily for 6 days) on the neural processing of emotional faces in 43 healthy participants using a randomised placebo-controlled design. Participants receiving prucalopride were more accurate at identifying the gender of emotional faces. In whole brain analyses, prucalopride was also associated with reduced activation in a network of regions corresponding to th

SUBMITTER: de Cates AN 

PROVIDER: S-EPMC9039209 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature