Protonation and anion-binding properties of aromatic sulfonylurea derivatives.

ABSTRACT: In this work the anion-binding properties of three aromatic sulfonylurea derivatives in acetonitrile and dimethyl sulfoxide were explored by means of NMR titrations. It was found that the studied receptors effectively bind anions of low basicity (Cl^-, Br^-, I^-, NO₃ ^- and HSO₄ ^-). The stoichiometry of the complexes with receptors containing one binding site was 1 : 1 exclusively, whereas in the case of the receptor containing two sulfonylurea groups 1 : 2 (receptor : anion) complexes were also detected in some cases. The presence of strongly basic anions (acetate and dihydrogen phosphate) led to the deprotonation of the sulfonylurea moiety. This completely hindered its anion-binding properties in DMSO and only proto

SUBMITTER: Barisic D 

PROVIDER: S-EPMC9039416 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature