Retinal Drusen Are More Common and Larger in Systemic Lupus Erythematosus With Renal Impairment.

ABSTRACT:

Introduction

Complement has been implicated in systemic lupus erythematosus (SLE) pathogenesis on the basis of the associations with inherited complement defects and genome-wide association study risk alleles, glomerular deposits, reduced serum levels, and occasional reports of retinal drusen. This study examined drusen in SLE and their clinical significance.

Methods

This cross-sectional observational study compared individuals with SLE recruited from renal and rheumatology clinics with hospital controls. Participants were reviewed for clinical features and underwent imaging with a nonmydriatic retinal camera. Deidentified images were examined by 2 trained graders for drusen number and size using a grid overlay.

Results

The cohort with SLE (n = 65) comprised 55

SUBMITTER: Ham YJ 

PROVIDER: S-EPMC9039474 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature