Integrating pore architectures to evaluate vascularization efficacy in silicate-based bioceramic scaffolds.

ABSTRACT: Pore architecture in bioceramic scaffolds plays an important role in facilitating vascularization efficiency during bone repair or orbital reconstruction. Many investigations have explored this relationship but lack integrating pore architectural features in a scaffold, hindering optimization of architectural parameters (geometry, size and curvature) to improve vascularization and consequently clinical outcomes. To address this challenge, we have developed an integrating design strategy to fabricate different pore architectures (cube, gyroid and hexagon) with different pore dimensions (∼350, 500 and 650 μm) in the silicate-based bioceramic scaffolds via digital light processing technique. The sintered scaffolds maintained high-fidelity pore architectures similar to the printing model. The

SUBMITTER: Wu F 

PROVIDER: S-EPMC9039507 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature