Angioregulatory microRNAs in breast cancer: Molecular mechanistic basis and implications for therapeutic strategies.

ABSTRACT:

Background

Cancer-associated angiogenesis is a fundamental process in tumor growth and metastasis. A variety of signaling regulators and pathways contribute to establish neovascularization, among them as small endogenous non-coding RNAs, microRNAs (miRNAs) play prominent dual regulatory function in breast cancer (BC) angiogenesis.

Aim of review

This review aims at describing the current state-of-the-art in BC angiogenesis-mediated by angioregulatory miRNAs, and an overview of miRNAs dysregulation association with the anti-angiogenic response in addition to potential clinical application of miRNAs-based therapeutics.

Key scientific concepts of review

Angioregulatory miRNA-target gene interaction is not only involved in sprouting vessels of breast tumors but also, trans

SUBMITTER: Soheilifar MH 

PROVIDER: S-EPMC9039675 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature