Prognostic Role and Potential Mechanisms of N6-methyladenosine-related Long Noncoding RNAs in Hepatocellular Carcinoma.

ABSTRACT:

Background and aims

Numerous studies have explored the important role of N6-methyladenosine (m⁶A) in cancer. Nonetheless, the interaction between m⁶A and long noncoding RNAs (lncRNAs) is poorly investigated. Herein, we systematically analyzed the role and prognostic value of m⁶A-related lncRNAs in hepatocellular carcinoma (HCC).

Methods

The m⁶A-related lncRNAs were identified based on the correlation coefficients with m⁶A-related genes in HCC from The Cancer Genome Atlas. Subsequently, a novel risk score model was determined using the least absolute shrinkage and selection operator Cox regression analyses. Univariate and multivariate Cox analyses were used to identify independent prognostic factors for overall survival (

SUBMITTER: Dai T 

PROVIDER: S-EPMC9039697 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature