Safe and efficient 2D molybdenum disulfide platform for cooperative imaging-guided photothermal-selective chemotherapy: A preclinical study.

ABSTRACT:

Introduction

The striking imbalance between the ever-increasing amount of nanomedicines and low clinical translation of products has become the focus of intense debate. For clinical translation, the critical issue is to select the appropriate agents and combination regimen for targeted diseases, not to prepare increasingly complex nanoplatforms.

Objectives

A safe and efficient platform, α-tocopheryl succinate (α-TOS) married 2D molybdenum disulfide, was devised by a facile method and applied for cooperative imaging-guided photothermal-selective chemotherapy of ovarian carcinoma.

Methods

A novel platform of PEGylated α-TOS and folic acid (FA) conjugated 2D MoS₂ nanoflakes was fabricated  for the cooperative multimode computed tomography (CT)/photoacoustic (P

SUBMITTER: Li X 

PROVIDER: S-EPMC9039738 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature