Dissecting and analyzing the Subclonal Mutations Associated with Poor Prognosis in Diffuse Glioma.

ABSTRACT: The prognostic and therapeutic implications in diffuse gliomas are still challenging. In this study, we first performed an integrative framework to infer the clonal status of mutations in glioblastomas (GBMs) and low-grade gliomas (LGGs) by using exome sequencing data from TCGA and observed both clonal and subclonal mutations for most mutant genes. Based on the clonal status of a given gene, we systematically investigated its prognostic value in GBM and LGG, respectively. Focusing on the subclonal mutations, our results showed that they were more likely to contribute to the poor prognosis, which could be hardly figured out without considering clonal status. These risk subclonal mutations were associated with some specific genomic features, such as genomic instability and intratumor heterog

SUBMITTER: Bai M 

PROVIDER: S-EPMC9039777 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature