Assessing immunological and virological responses in the liver: Implications for the cure of chronic hepatitis B virus infection.

ABSTRACT: Cure from chronic HBV infection is rare with current therapies. Basic research has helped to fundamentally improve our knowledge of the viral life cycle and virus-host interactions, and provided the basis for several novel drug classes that are currently being developed or are being tested in clinical trials. While these novel compounds targeting the viral life cycle or antiviral immune responses hold great promise, we are still lacking a comprehensive understanding of the immunological and virological processes that occur at the site of infection, the liver. At the International Liver Congress 2021 (ILC 2021), a research think tank on chronic HBV infection focused on mechanisms within the liver that facilitate persistent infection and looked at the research questions that need to be addre

SUBMITTER: Boettler T 

PROVIDER: S-EPMC9039841 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature