The Density of Renal Lymphatics Correlates With Clinical Outcomes in IgA Nephropathy.

ABSTRACT:

Introduction

IgA nephropathy (IgAN) is the most common primary glomerulonephritis (GN) worldwide. The disease course fluctuates, and the most important challenge is the considerable variation in the time lag between diagnosis and the development of a hard clinical end point, such as end-stage kidney disease (ESKD). The reaction of renal tissue to damage resembles the common wound-healing response. One part of this repair in IgAN is the expansion of lymphatic vessels known as lymphangiogenesis. The aim of this work was to establish the prognostic value of the density of lymphatic vessels in the renal biopsy at the time of diagnosis, for predicting the risk of ESKD in a Spanish cohort of patients with IgAN.

Methods

We performed a retrospective multicenter study of 76 patients

SUBMITTER: Rodas L 

PROVIDER: S-EPMC9039908 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature