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Terpenes and terpenoids as main bioactive compounds of essential oils, their roles in human health and potential application as natural food preservatives.

ABSTRACT: Essential oils (EOs) are volatile and concentrated liquids extracted from different parts of plants. Bioactive compounds found in EOs, especially terpenes and terpenoids possess a wide range of biological activities including anticancer, antimicrobial, anti-inflammatory, antioxidant, and antiallergic. Available literature confirms that EOs exhibit antimicrobial and food preservative properties that are considered as a real potential application in food industry. Hence, the purpose of this review is to present an overview of current knowledge of EOs for application in pharmaceutical and medical industries as well as their potential as food preservatives in food industry.

SUBMITTER: Masyita A

PROVIDER: S-EPMC9039924 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Terpenes and terpenoids as main bioactive compounds of essential oils, their roles in human health and potential application as natural food preservatives.

Masyita Ayu A Mustika Sari Reka R Dwi Astuti Ayun A Yasir Budiman B Rahma Rumata Nur N Emran Talha Bin TB Nainu Firzan F Simal-Gandara Jesus J

Food chemistry: X 20220119

Essential oils (EOs) are volatile and concentrated liquids extracted from different parts of plants. Bioactive compounds found in EOs, especially terpenes and terpenoids possess a wide range of biological activities including anticancer, antimicrobial, anti-inflammatory, antioxidant, and antiallergic. Available literature confirms that EOs exhibit antimicrobial and food preservative properties that are considered as a real potential application in food industry. Hence, the purpose of this review ...[more]

PMID: 35498985

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Project description:BackgroundThe rise of antibiotic resistance imposes the search for novel antimicrobial strategies as natural products or its combination with antibiotics. This study investigates the synergistic effects of terpenoids from Cissampelos oppositifolia (C. oppositifolia) essential oil in combination with antibiotics against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The aims were to evaluate the antimicrobial efficacy, analyze functional group modifications and assess molecular interaction.MethodsEssential oil was extracted from C. oppositifolia by hydro-distillation. The EO was analyzed for terpenoid content via Thin Layer Chromatography (TLC). Antimicrobial activity was assessed using the disc diffusion method and Minimum Inhibitory Concentration determinations (MIC) by broth dilution followed by bactericidal essay (Time-killing). FTIR and UV spectroscopy were employed to detect functional group modifications in terpenoid-antibiotic combinations. Molecular docking studies assessed interaction energies between terpenoids and antibiotics.ResultsTLC identified α-pinene, δ-carene, and caryophyllene in the EO. δ-Carene exhibited the highest synergy with antibiotics, showing the lowest MIC of 0.04 mg/mL against S. aureus ATCC-43300 and 0.05 mg/mL against E. coli MTCC-739. Time-kill assays demonstrated that α-pinene, δ-carene, and caryophyllene achieved complete bacterial eradication by 4 hours in combination with amoxicillin against E. coli, and by 2 hours against S. aureus in combination with erythromycin. FTIR analysis revealed peak shifts at 1599, 1774, and 2259 cm-1 for amoxicillin + α-pinene, and new peaks at 1648 and 1287 cm-1 for δ-carene + erythromycin. UV spectra indicated potential complex formations. Docking studies showed δ-carene's strong interaction with erythromycin and amoxicillin, with interaction energies of -96.10 and -87.75 kcal/mol, respectively.ConclusionTerpenoids from C. oppositifolia enhance the antimicrobial efficacy of antibiotics. Functional group modifications and complex formations suggest that these interactions may contribute to synergistic effects. These findings support the potential use of terpenoid-antibiotic combinations in overcoming antibiotic resistance and warrant further investigation into their mechanisms of action.

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Terpenes and terpenoids as main bioactive compounds of essential oils, their roles in human health and potential application as natural food preservatives.

Publications

Terpenes and terpenoids as main bioactive compounds of essential oils, their roles in human health and potential application as natural food preservatives.

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