Shared acute phase traits in effector and memory human CD8 T cells.

ABSTRACT: CD8 T cells have multiple functional properties that mediate acute phase and long-term immune protection. Several effector and memory CD8 T cell subsets have been described with diverse functionalities and marker profiles. In contrast to the many comprehensive mouse studies, most human studies lack samples from the acute infection phase, a major reason why current knowledge of human T cell subsets and differentiation remains incomplete, particularly with regard to the T cell heterogeneity early during the immune response. Here we analysed the human CD8 T cell response to yellow fever vaccination as the best-known model to study the human immune response to acute viral infection. We performed flow cytometry on 21 markers conventionally used in mice and in humans to describe differentiation,

SUBMITTER: Fuertes Marraco SA 

PROVIDER: S-EPMC9040096 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature