Cardiovascular Disease Among Patients With AML and CHIP-Related Mutations.

ABSTRACT:

Background

Clonal hematopoiesis of indeterminate potential (CHIP) is a novel cardiovascular disease (CVD) risk factor in individuals without acute myeloid leukemia (AML).

Objectives

The aim of this study was to examine the association between mutations associated with CHIP (CHIP-related mutations) identified in patients at AML diagnosis and the risk for cardiovascular events (CVEs).

Methods

This was a retrospective cohort study of 623 patients with AML treated between 2015 and 2018 who underwent DNA analysis. Cause-specific hazard regression models were used to study the associations between pathogenic mutations in common CHIP-related genes (DNMT3A, TET2, ASXL1, JAK2, TP53, SRSF2, and SF3B1) and the rate of CVEs (heart

SUBMITTER: Calvillo-Arguelles O 

PROVIDER: S-EPMC9040128 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature