Extracellular vesicles derived from head and neck squamous cells carcinoma inhibit NLRP3 inflammasomes.

ABSTRACT: The content of tumor-derived extracellular vesicles (EVs) can regulate the tumor microenvironment and functionally acts in favor of cancer aggressiveness. To better elucidate the role of EVs in the interplay between immune system and tumor microenvironment, the purpose of this study was to analyze the effect of head and neck squamous cells carcinoma (HNSCC)-derived EVs on the modulation of inflammasomes - mediators of pyroptosis and secretion of inflammatory factors by macrophages. Our results showed that macrophages treated with the Vesicular Secretome Fraction (VSF) isolated from patient-derived HNSCC presented a reduction in the secretion of mature IL-1β and caspase-1 without affecting cell viability. An analysis of the protein content of HNSCC-derived VSF by antibody array revealed tha

SUBMITTER: Bottino LZMF 

PROVIDER: S-EPMC9040134 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature