Pegylation of phenothiazine - A synthetic route towards potent anticancer drugs.

ABSTRACT:

Introduction

Cancer is a big challenge of the 21 century, whose defeat requires efficient antitumor drugs.

Objectives

The paper aims to investigate the synergistic effect of two structural building blocks, phenothiazine and poly(ethylene glycol), towards efficient antitumor drugs.

Methods

Two PEGylated phenothiazine derivatives were synthetized by attaching poly(ethylene glycol) of 550 Da to the nitrogen atom of phenothiazine by ether or ester linkage. Their antitumor activity has been investigated on five human tumour lines and a mouse tumor line as well, by determination of IC50. The in vivo toxicity was determined by measuring the LD50 in BALB/c mice by the sequential method and the in vivo antitumor potential was measured by the tumours growth test.

SUBMITTER: Cibotaru S 

PROVIDER: S-EPMC9040145 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature