Antibacterial activities and action mode of anti-hyperlipidemic lomitapide against Staphylococcus aureus.

ABSTRACT:

Background

The increasing emergence of multidrug-resistant Gram-positive bacterial infections necessitates new antibacterial agents with novel mechanisms of action that can be used to treat these infections. Lomitapide has been approved by FDA for years in reducing levels of low-density lipoprotein (LDL) in cases of familial hypercholesterolemia, whereas the antibacterial effect of lomitapide remains elusive. In this study, the inhibitory activities of lomitapide against Gram-positive bacteria were the first time explored. Quantitative proteomics analysis was then applied to investigate the mechanisms of action of lomitapide.

Results

The minimum inhibitory concentration (MIC) values of lomitapide against Gram-positive bacteria including both methicillin sensitive and resista

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9040290 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature