Evening versus morning dosing regimen drug therapy for hypertension.

ABSTRACT:

Background

Variation in blood pressure levels display circadian rhythms. The morning surge in blood pressure is known to increase the risk of myocardial events in the first several hours post awakening. A systematic review of the administration-time-related-effects of evening versus morning dosing regimen of antihypertensive drugs in the management of patients with primary hypertension has not been conducted.

Objectives

To evaluate the administration-time-related-effects of antihypertensive drugs administered as once daily monotherapy in the evening versus morning administration regimen on all cause mortality, cardiovascular morbidity and reduction of blood pressure in patients with primary hypertension.

Search strategy

We searched Cochrane CENTRAL on Ovid (4th Quarte

SUBMITTER: Zhao P 

PROVIDER: S-EPMC9040377 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature