Distinct N and C Cross-Feeding Networks in a Synthetic Mouse Gut Consortium.

ABSTRACT: The complex interactions between the gut microbiome and host or pathogen colonization resistance cannot be understood solely from community composition. Missing are causal relationships, such as metabolic interactions among species, to better understand what shapes the microbiome. Here, we focused on metabolic niches generated and occupied by the Oligo-Mouse-Microbiota (OMM) consortium, a synthetic community composed of 12 members that is increasingly used as a model for the mouse gut microbiome. Combining monocultures and spent medium experiments with untargeted metabolomics revealed broad metabolic diversity in the consortium, constituting a dense cross-feeding network with more than 100 pairwise interactions. Quantitative analysis of the cross-feeding network revealed distinct C and N f

SUBMITTER: Perez Escriva P 

PROVIDER: S-EPMC9040589 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature