Antioxidant and anti-aging potential of a peptide formulation (Gal₂-Pep) conjugated with gallic acid.

ABSTRACT: Skin is highly vulnerable to premature aging due to external stress, therefore, in this study, a peptide formulation, (galloyl)₂-KTPPTTP (Gal₂-Pep) was synthesized by combining TPPTTP peptide, and gallic acid (GA). All peptides were synthesized on 2-chlorotrityl chloride resin using solid-phase peptide synthesis (SPPS), and analyzed on an electrospray ionization (ESI)/quadrupole-time-of-flight (Q-TOF) tandem mass spectroscopy (MS) system. Initially, Gal₂-Pep showed no toxicity below the concentration 100 μM with cell survival rate of 88% for keratinocytes and fibroblasts. The reactive oxygen species (ROS) scavenging activity of Gal₂-Pep was more stable compared to GA alone; and after four weeks at room temperature, its ROS scavenging activity rem

SUBMITTER: Lee H 

PROVIDER: S-EPMC9040627 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature