The Role of Interstitial Fluid Pressure in Cerebral Porous Biomaterial Integration.

ABSTRACT: Recent advances in biomaterials offer new possibilities for brain tissue reconstruction. Biocompatibility, provision of cell adhesion motives and mechanical properties are among the present main design criteria. We here propose a radically new and potentially major element determining biointegration of porous biomaterials: the favorable effect of interstitial fluid pressure (IFP). The force applied by the lymphatic system through the interstitial fluid pressure on biomaterial integration has mostly been neglected so far. We hypothesize it has the potential to force 3D biointegration of porous biomaterials. In this study, we develop a capillary hydrostatic device to apply controlled in vitro interstitial fluid pressure and study its effect during 3D tissue culture. We find that the IFP is a

SUBMITTER: Bonini F 

PROVIDER: S-EPMC9040716 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature