SmdA is a Novel Cell Morphology Determinant in Staphylococcus aureus.

ABSTRACT: Cell division and cell wall synthesis in staphylococci need to be precisely coordinated and controlled to allow the cell to multiply while maintaining its nearly spherical shape. The mechanisms ensuring correct placement of the division plane and synthesis of new cell wall have been studied intensively. However, hitherto unknown factors and proteins are likely to play key roles in this complex interplay. Here, we identified and investigated a protein with a major influence on cell morphology in Staphylococcus aureus. The protein, named SmdA (for staphylococcal morphology determinant A), is a membrane protein with septum-enriched localization. By CRISPRi knockdown and overexpression combined with different microscopy techniques, we demonstrated that proper levels of SmdA were necessary for

SUBMITTER: Myrbraten IS 

PROVIDER: S-EPMC9040797 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature