Multiple Hybridization Events Punctuate the Evolutionary Trajectory of Malassezia furfur.

ABSTRACT: Malassezia species are important fungal skin commensals and are part of the normal microbiota of humans and other animals. However, under certain circumstances these fungi can also display a pathogenic behavior. For example, Malassezia furfur is a common commensal of human skin and yet is often responsible for skin disorders but also systemic infections. Comparative genomics analysis of M. furfur revealed that some isolates have a hybrid origin, similar to several other recently described hybrid fungal pathogens. Because hybrid species exhibit genomic plasticity that can impact phenotypes, we sought to elucidate the genomic evolution and phenotypic characteristics of M. furfur hybrids in comparison to their parental lineages. To this end, we performed a comparat

SUBMITTER: Theelen B 

PROVIDER: S-EPMC9040865 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature