ZnCl₂-promoted domino reaction of 2-hydroxybenzonitriles with ketones for synthesis of 1,3-benzoxazin-4-ones.

ABSTRACT: A ZnCl₂-promoted synthesis of 1,3-benzoxazin-4-one from 2-hydroxybenzonitriles and ketones was developed. This method displays facile access to a diverse range of substituted 1,3-benzoxazin-4-ones in good yields. This synthetic protocol has advantages: (i) easy availability of starting material; (ii) strong corrosive acid-free condition; (iii) high yield.

SUBMITTER: Su Z 

PROVIDER: S-EPMC9040917 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature