Germline pathogenic variants in cancer risk genes among patients with thyroid cancer and suspected predisposition.

ABSTRACT:

Purpose

Multigene panels allow simultaneous testing of genes involved in cancer predisposition. Thyroid cancer (TCa) is a component tumor of several cancer predisposition syndromes, but the complete landscape of germline variants predisposing to TCa remains to be determined.

Methods

Clinical information and genetic test results were reviewed from over 170,000 individuals who had multigene panel testing for hereditary cancer at a single diagnostic laboratory. Germline pathogenic and likely pathogenic variants ("pathogenic variants") were examined among individuals with TCa. A cohort with breast cancer (BCa) was examined to serve as a comparison group and to determine the added contribution of TCa to the ascertainment of genetic risk.

Results

Of 3134 individuals with TC

SUBMITTER: Kamihara J 

PROVIDER: S-EPMC9041070 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature