Hepatocellular carcinoma after a sustained virological response by direct-acting antivirals harbors TP53 inactivation.

ABSTRACT:

Introduction

The genomic characteristics of hepatocellular carcinoma (HCC) after a sustained virological response (SVR) and its differences according to whether an SVR was achieved by treatment with direct-acting antivirals (DAA) or interferon (IFN) are still not fully understood.

Methods

Sixty-nine surgically resected HCCs from patients with hepatitis C virus infection were analyzed by gene expression profiling and whole-exome sequencing.

Results

Among the 69 HCC patients, 34 HCCs in which an SVR was not achieved at the time of surgery were classified as HCV-positive, and 35 HCCs in which an SVR was achieved at the time of surgery were classified as HCV-SVR. According to the HCV treatment, 35 HCV-SVR HCCs were classified into two groups: eight tumors with DAA (HCV-SV

SUBMITTER: Imamura T 

PROVIDER: S-EPMC9041076 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature