An efficient synthesis of RNA containing GS-441524: the nucleoside precursor of remdesivir.

ABSTRACT: Remdesivir is an antiviral nucleoside phosphoramidate with activity against multiple viruses, including SARS-CoV-2. To enable studies of viral polymerases with RNA containing remdesivir, we report an efficient synthesis of a phosphoramidite of GS-441524, the nucleoside precursor of remdesivir, and its incorporation into RNA using automated solid-phase RNA synthesis.

SUBMITTER: Moorthy R 

PROVIDER: S-EPMC9041347 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature