Project description:Immunotherapy represents the third important wave in the history of the systemic treatment of cancer after chemotherapy and targeted therapy and is now established as a potent and effective treatment option across several cancer types. The clinical success of anti-cytotoxic T-lymphocyte-associated antigen (CTLA)-4, first, and anti-programmed death (PD)-1/PD-ligand (L)1 agents in melanoma and other cancers a few years later, has encouraged increasing focus on the development of other immunotherapies (e.g. monoclonal antibodies with other immune targets, adoptive cell transfer, and vaccines), with over 3000 immuno-oncology trials ongoing, involving hundreds of research institutes across the globe. The potential use of these different immunotherapeutic options in various combinations with one another and with other treatment modalities is an area of particular promise. The third Immunotherapy Bridge meeting (29-30 November, 2017, Naples, Italy) focused on recent advances in immunotherapy across various cancer types and is summarised in this report.

| S-EPMC6042369 | biostudies-literature

Meeting report: the 2021 FSHD International Research Congress.

Project description:Facioscapulohumeral muscular dystrophy (FSHD) is the second most common genetic myopathy, characterized by slowly progressing and highly heterogeneous muscle wasting with a typical onset in the late teens/early adulthood [1]. Although the etiology of the disease for both FSHD type 1 and type 2 has been attributed to gain-of-toxic function stemming from aberrant DUX4 expression, the exact pathogenic mechanisms involved in muscle wasting have yet to be elucidated [2-4]. The 2021 FSHD International Research Congress, held virtually on June 24-25, convened over 350 researchers and clinicians to share the most recent advances in the understanding of the disease mechanism, discuss the proliferation of interventional strategies and refinement of clinical outcome measures, including results from the ReDUX4 trial, a phase 2b clinical trial of losmapimod in FSHD [NCT04003974].

| S-EPMC8762812 | biostudies-literature

Meeting report: the 2020 FSHD International Research Congress.

Project description: Not available

| S-EPMC7721607 | biostudies-literature

20th IUPAB International Congress, 45th SBBf Congress and 50th Annual Meeting of SBBq : Poster Abstracts

Project description: Not available

| S-EPMC8551951 | biostudies-literature

"French Phage Network"-Second Meeting Report.

Project description:The study of bacteriophages (viruses of bacteria) includes a variety of approaches, such as structural biology, genetics, ecology, and evolution, with increasingly important implications for therapeutic and industrial uses. Researchers working with phages in France have recently established a network to facilitate the exchange on complementary approaches, but also to engage new collaborations. Here, we provide a summary of the topics presented during the second meeting of the French Phage Network that took place in Marseille in November 2016.

| S-EPMC5408693 | biostudies-literature

Abstracts of the 4th International WAVEX Meeting: Whole Body Vibration as an intervention in physical and mental health 29-30 October 2021 (Virtual).

Project description: Not available

| S-EPMC8672407 | biostudies-literature

Abstracts of the 24th Annual Congress of the SBRA, 2020 (Virtual Meeting).

Project description: Not available

| S-EPMC7558887 | biostudies-literature

Modeling the effect of transient populations on epidemics in Washington DC.

Project description:Large numbers of transients visit big cities, where they come into contact with many people at crowded areas. However, epidemiological studies have not paid much attention to the role of this subpopulation in disease spread. We evaluate the effect of transients on epidemics by extending a synthetic population model for the Washington DC metro area to include leisure and business travelers. A synthetic population is obtained by combining multiple data sources to build a detailed minute-by-minute simulation of population interaction resulting in a contact network. We simulate an influenza-like illness over the contact network to evaluate the effects of transients on the number of infected residents. We find that there are significantly more infections when transients are considered. Since much population mixing happens at major tourism locations, we evaluate two targeted interventions: closing museums and promoting healthy behavior (such as the use of hand sanitizers, covering coughs, etc.) at museums. Surprisingly, closing museums has no beneficial effect. However, promoting healthy behavior at the museums can both reduce and delay the epidemic peak. We analytically derive the reproductive number and perform stability analysis using an ODE-based model.

| S-EPMC3818653 | biostudies-literature

Hepatitis B Vaccine Refusal Trends in Washington, DC, Newborns, 2017-2022.

Project description: Not available

| S-EPMC11240185 | biostudies-literature