Ex Vivo Test for Measuring Complement Attack on Endothelial Cells: From Research to Bedside.

ABSTRACT: As part of the innate immune system, the complement system plays a key role in defense against pathogens and in host cell homeostasis. This enzymatic cascade is rapidly triggered in the presence of activating surfaces. Physiologically, it is tightly regulated on host cells to avoid uncontrolled activation and self-damage. In cases of abnormal complement dysregulation/overactivation, the endothelium is one of the primary targets. Complement has gained momentum as a research interest in the last decade because its dysregulation has been implicated in the pathophysiology of many human diseases. Thus, it appears to be a promising candidate for therapeutic intervention. However, detecting abnormal complement activation is challenging. In many pathological conditions, complement activation occur

SUBMITTER: Meuleman MS 

PROVIDER: S-EPMC9041553 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature