Iron(iii) chelated paramagnetic polymeric nanoparticle formulation as a next-generation T ₁-weighted MRI contrast agent.

ABSTRACT: Magnetic resonance imaging (MRI) is a routinely used imaging technique in medical diagnostics. To enhance the quality of MR images, contrast agents (CAs) are used, which account for nearly 40% of MRI exams in the clinic globally. The most used CAs are gadolinium-based CAs (GBCAs) but the use of GBCAs has been linked with metal-deposition in vital organs. Gadolinium deposition has been shown to be correlated with nephrogenic systemic fibrosis, a fibrosis of the skin and internal organs. Therefore, there is an unmet need for a new CA alternative to GBCAs for T ₁-weighted Ce-MRI. Herein, we designed paramagnetic ferric iron(iii) ion-chelated poly(lactic-co-glycolic)acid nanoparticle formulation and routinely examined their application in Ce-MRI using clinical and ultr

SUBMITTER: Marasini R 

PROVIDER: S-EPMC9041822 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature