Sub-micrometer morphology of human atherosclerotic plaque revealed by synchrotron radiation-based μCT-A comparison with histology.

ABSTRACT: Histology is a long standing and well-established gold standard for pathological characterizations. In recent years however, synchrotron radiation-based micro-computed tomography (SRμCT) has become a tool for extending the imaging of two-dimensional thin sections into three-dimensional imaging of tissue blocks, enabling so-called virtual histology with arbitrary clipping planes, volumetric rendering and automatic segmentation. In this study, we present a thorough characterization of human carotid plaques after endarterectomy of patients with stroke or transient ischemic attack (TIA), investigating several different pathologic structures using both SRμCT and histology. Phase-contrast SRμCT was performed with two different magnifications (voxel sizes 6.5 μm and 0.65 μm, respectively), and hi

SUBMITTER: Truong M 

PROVIDER: S-EPMC9041845 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature