Variational Bayesian inference for association over phylogenetic trees for microorganisms.

ABSTRACT: With the advance of next generation sequencing technologies, researchers now routinely obtain a collection of microbial sequences with complex phylogenetic relationships. It is often of interest to analyze the association between certain environmental factors and characteristics of the microbial collection. Though methods have been developed to test for association between the microbial composition with environmental factors as well as between coevolving traits, a flexible model that can provide a comprehensive picture of the relationship between microbial community characteristics and environmental variables will be tremendously beneficial. We developed a Bayesian approach for association analysis while incorporating the phylogenetic structure to account for the dependence between observa

SUBMITTER: Hao X 

PROVIDER: S-EPMC9041926 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature