Link between obsessive-compulsive disorder and polymorphisms in HDAC genes.

ABSTRACT:

Objective

Recently, epigenetic mechanisms related to histone modifications including histone deacetylation (HDAC) have been emphasized in psychiatric diseases. Few studies have investigated the relationship of HDAC gene variations to psychiatric diseases, but these gene variations have never been studied in obsessive-compulsive disorder (OCD). The present case-control study aimed to compare symptomatology with HDAC gene variations in patients with OCD.

Methods

Illumina next-generation sequencing of six HDAC genes (HDAC2,3,4,9,10,11) was performed on DNA samples isolated from 200 Turkish subjects recruited from routine clinical practice. Twenty-seven single nucleotide polymorphism (SNPs) in six HDAC genes were scanned with the LightSNiP method.

Results

New variants, al

SUBMITTER: Dondu A 

PROVIDER: S-EPMC9041966 | biostudies-literature | 2022 Mar-Abr

REPOSITORIES: biostudies-literature