Candidate-gene association analysis for a continuous phenotype with a spike at zero using parent-offspring trios.

ABSTRACT: In this paper, we propose the class of generalized additive models for location, scale and shape in a test for the association of genetic markers with non-normally distributed phenotypes comprising a spike at zero. The resulting statistical test is a generalization of the quantitative transmission disequilibrium test with mating type indicator, which was originally designed for normally distributed quantitative traits and parent-offspring data. As a motivational example, we consider coronary artery calcification (CAC), which can accurately be identified by electron beam tomography. In the investigated regions, individuals will have a continuous measure of the extent of calcium found or they will be calcium-free. Hence, the resulting distribution is a mixed discrete-continuous distribution

SUBMITTER: Klein N 

PROVIDER: S-EPMC9042123 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature