Dataset Information

The Digital Brain Bank, an open access platform for post-mortem imaging datasets.

ABSTRACT: Post-mortem magnetic resonance imaging (MRI) provides the opportunity to acquire high-resolution datasets to investigate neuroanatomy and validate the origins of image contrast through microscopy comparisons. We introduce the Digital Brain Bank (open.win.ox.ac.uk/DigitalBrainBank), a data release platform providing open access to curated, multimodal post-mortem neuroimaging datasets. Datasets span three themes-Digital Neuroanatomist: datasets for detailed neuroanatomical investigations; Digital Brain Zoo: datasets for comparative neuroanatomy; and Digital Pathologist: datasets for neuropathology investigations. The first Digital Brain Bank data release includes 21 distinctive whole-brain diffusion MRI datasets for structural connectivity investigations, alongside microscopy and complementary MRI modalities. This includes one of the highest-resolution whole-brain human diffusion MRI datasets ever acquired, whole-brain diffusion MRI in fourteen nonhuman primate species, and one of the largest post-mortem whole-brain cohort imaging studies in neurodegeneration. The Digital Brain Bank is the culmination of our lab's investment into post-mortem MRI methodology and MRI-microscopy analysis techniques. This manuscript provides a detailed overview of our work with post-mortem imaging to date, including the development of diffusion MRI methods to image large post-mortem samples, including whole, human brains. Taken together, the Digital Brain Bank provides cross-scale, cross-species datasets facilitating the incorporation of post-mortem data into neuroimaging studies.

SUBMITTER: Tendler BC

PROVIDER: S-EPMC9042233 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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The Digital Brain Bank, an open access platform for post-mortem imaging datasets.

Tendler Benjamin C BC Hanayik Taylor T Ansorge Olaf O Bangerter-Christensen Sarah S Berns Gregory S GS Bertelsen Mads F MF Bryant Katherine L KL Foxley Sean S van den Heuvel Martijn P MP Howard Amy F D AFD Huszar Istvan N IN Khrapitchev Alexandre A AA Leonte Anna A Manger Paul R PR Menke Ricarda A L RAL Mollink Jeroen J Mortimer Duncan D Pallebage-Gamarallage Menuka M Roumazeilles Lea L Sallet Jerome J Scholtens Lianne H LH Scott Connor C Smart Adele A Turner Martin R MR Wang Chaoyue C Jbabdi Saad S Mars Rogier B RB Miller Karla L KL

eLife 20220317

Post-mortem magnetic resonance imaging (MRI) provides the opportunity to acquire high-resolution datasets to investigate neuroanatomy and validate the origins of image contrast through microscopy comparisons. We introduce the <i>Digital Brain Bank</i> (open.win.ox.ac.uk/DigitalBrainBank), a data release platform providing open access to curated, multimodal post-mortem neuroimaging datasets. Datasets span three themes<i>-Digital Neuroanatomist</i>: datasets for detailed neuroanatomical investigat ...[more]

PMID: 35297760

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Dataset Information

The Digital Brain Bank, an open access platform for post-mortem imaging datasets.

Publications

The Digital Brain Bank, an open access platform for post-mortem imaging datasets.

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