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DIBALH: from known fundamental to an unusual reaction; chemoselective partial reduction of tertiary amides in the presence of esters.

ABSTRACT: This study presents a quick and reliable approach to the chemoselective partial reduction of tertiary amides to aldehydes in the presence of readily reducible ester groups using commercial DIBALH reagent. Moreover, the developed method was also extended to multi-functional molecules bearing ester moieties, which were successfully chemoselectively reduced to the corresponding aldehydes.

SUBMITTER: Heo YJ

PROVIDER: S-EPMC9042244 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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DIBALH: from known fundamental to an unusual reaction; chemoselective partial reduction of tertiary amides in the presence of esters.

Heo Yu Jin YJ Kim Hyun Tae HT Jaladi Ashok Kumar AK An Duk Keun DK

RSC advances 20211018 53

This study presents a quick and reliable approach to the chemoselective partial reduction of tertiary amides to aldehydes in the presence of readily reducible ester groups using commercial DIBALH reagent. Moreover, the developed method was also extended to multi-functional molecules bearing ester moieties, which were successfully chemoselectively reduced to the corresponding aldehydes. ...[more]

PMID: 35497556

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